This discovery will bring back youth. We BEAT aging?
Unfortunately, the aging process affects not only a person’s appearance but also his physical and mental abilities. With age, people become more inattentive, their organism becomes less resistant to diseases, and the body is not able to tolerate heavy physical activity.
All this forces a person to abandon the usual way of life. But few of us are able to accept this. Many people try to find a “recipe for eternal youth”. They use various supplements in the hope of keeping their body and mind young. Millions of women around the world resort to plastic surgeons to preserve their beauty. But all these measures are temporary or completely useless.
However, there are claims from scientists that they have found the “recipe for eternal youth” that the whole world dreams of. It is worth noting that similar statements were made before but people did not get the desired effect. However, the technical equipment of modern scientists is constantly improving, and today they have powerful tools for making new discoveries. So, maybe they really managed to figure out how to defeat aging?
Hello friends! Over time, our body and brain begin to lose their former abilities and powers, and then inevitably comes old age. In old age, people can no longer boast of the health and sharpness of mind that they had in their youth, but what if this can be avoided and the lost years reversed?
Australian biologist and Professor of genetics David Sinclair is confident that he is on the verge of a great discovery and will soon be able to extend human life, while making it healthier. Scientists like Professor Sinclair have evidence of both acceleration and deceleration of aging. To understand what it looks like and how it happens, it’s worth a look at his lab, which is located North of San Francisco. In this place, lunar jellyfish are studied, which some believe are immortal. These creatures have a complex life cycle in which they start as a polyp similar to a small sea anemone, and after undergoing metamorphosis turn into jellyfish.
In most of these species, polyps can reproduce asexually and regenerate after damage.
In addition, they do not have clear indicators of aging that correspond to this biological term. Thus, these representatives of the marine world do not have a certain degree of immortality, but to understand whether they will help us prolong life, it is necessary to answer the main question, how do we actually age?
Every cell in our body has the same DNA, but their different types have different epigenomes. They have different ways of packing this gene chain and chemical signaling markers that are placed on the double helix in certain positions. Epigenetics allows different types of cells to perform their specific functions. They distinguish brain cells from skin cells. Thus, the epigenome is responsible for turning various parts of DNA on or off, this happens with proteins called histones.
The idea is that when your body is just forming an epigenome tells your cells what type they should be, but when you get older, according to the Professor’s theory, you lose information in the epigenome and this is important, because if this skin cell is then it should remain it, and in the absence of such control, the cell will forget its purpose and can begin to mutate. Our DNA is constantly destroyed by ultraviolet and x-ray radiation, when our body restores this damage, the epigenome is not completely reset and as a result is shortened. After that, our cells no longer perform their functions as before, that is, we age. And indeed, as we get older, the following changes occur. After 50 years, the brain begins to break down faster and over the next 30 years it becomes 10% lighter, and its volume decreases by almost 15 %. Muscle mass is reduced at a rate of up to 2% per year. Deteriorating eyesight, developing osteoporosis and other diseases of the joints show signs of wear and tear of the bones. The body withers, but is it possible to avoid this? If such a factor really causes aging, then a group of experts led by Professor Sinclair is ready to take the first steps trying to preserve epigenomes to slow down the rate of aging in our body. In comfortable conditions, microorganisms used their resources for growth and reproduction, while in aggressive environments they switched to protection and recovery. During activation, they create enzymes that support the epigenome, these elements include our General protection against aging, based on the data obtained, the Professor concluded that there is a certain mechanism for slowing the rate of aging of the body.
The idea is that for self-healing, the body needs a signal from the outside in the form of light stress, this can be any aerobic exercise-running, dancing, or long walks. You need to get out of your comfort zone, that is, to resist aging, you need to give the body additional load, do physical exercises, or at least just harden up. In this case, when the body receives a signal about a potential danger, it will start independently the processes necessary to restore and slow down aging. Reversing aging requires an epigenetic reset, as we know all the information about us is written in our genes, but this value is already the last century. A new science has entered the arena, telling us that we are not victims of genetics, but that epigenetics actually governs everything. Its essence is that our way of life, food, movement, sleep and emotions, with the help of a system of special tags, are able to turn on and off certain genes. A restart may be possible using the Yamanaka factors.
These 4 factors can turn an adult cell into a stem cell, that is, reload it. Professor Sinclair used 3 of 4 factors to reverse the aging process in the retinal cells of old mice. So scientists were able to reverse the aging process in the cells of experimental subjects.
The experiment shows that after the elderly animals began to receive a certain component, the processes of restoring age-related damage to the double chain began in their body. The cells of the human body at some point lose their ability to recover, but according to Sinclair, the NAD + molecule is the key to freezing the aging process. This element plays an important role in redox reactions occurring in the body.
So the scientists carried out experiments to increase the level of NAD+ in the body of mice and observed a positive effect.
The increase in the level of the substance over a short period of time triggered the mechanisms of “repair” of DNA, which were destroyed with age in these individuals. The mechanism not only prevented further damage to the DNA, but was also able to heal some existing damage, so the subjects for example began to see again. But it is impossible to apply such gene therapy to each of the trillions of cells, so a different way will be needed to fully use the technique. And here jellyfish can come to the rescue. any cell of an adult individual of this creature can be reloaded at an earlier stage of its life cycle. It can become a polyp again after the maturation phase, it seems that the jellyfish is actually able to activate something like Yamanaka factors and reset epigenomes early in their life. It remains to find out how they do it and whether the technology will be compatible with the human body!
In the case of jellyfish, while few people understand and want to Fund these studies, perhaps someone just does not benefit from people defeating aging? And how do you think scientists will be able to solve the mystery of immortality and whether a person can overcome old age forever? Although there are no specific means for rejuvenation yet, we can still prolong youth simply by introducing a healthy active lifestyle and of course leaving the comfort zone.